HNRNPA1 and tropical spastic paraparesis: Polyglutamine binding protein-1 (PQBP1), an RNA binding protein that forms nuclear speckles and has a low complexity domain/intrinsically denatured domain, is also an hnRNP.54 In other neurological diseases, antibodies against hnRNPA1 were detected in HAM/TSP patients.55, 56