For instance, mutations of hnRNPA1 were reported with ALS patients,22 the aggregate protein in neurons of FTLD (TDP43) is an hnRNP by itself and interacts with hnRNPA2,49 hnRNPA2B1 was implicated in Fragile X-associated tremor/ataxia syndrome (FXTAS) and shown to bind with riboCGG repeat,50 TDP43 compensate the impairment by loss of hnRNPA2B1 in fly model,33 hnRNPA3 binds to GGGGCC repeats in FTLD-ALS linked to C9orf72,51 selective deficiency of hnRNP in entorhinal cortices of AD patients and the model were reported,52 AUUCU expansion of Ataxin-10 impairs the functon of hnRNPK,53 and so on. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.