In agreement with a previous study,21 phosphorylation of Tau at the AT8 epitope was not changed in premanifest mice (Figures 4a–c), whereas a significant increase was observed after the onset of the disease when compared with WT mice, suggesting that mHtt can induce Tau hyperphosphorylation with the progression of HD hippocampal pathology. This evidence concerns the gene MAPT and Huntington disease.