For the hormonal remission rate of ACTH adenomas, six mononostril (n = 81) and ten binostril (n = 257) studies reported relevant data, the random pool estimates being 80.3% (95% CI, 66.6–94.0) and 80.9% (95% CI, 72.0–89.8) in the mononostril and the binostril approache, respectively (S12 and S13 Figs). The gene discussed is POMC; the disease is adenoma.