When the diagnostic performance of AT1-AA for pre-eclampsia or non-gravid hypertension subgroups was calculated independently, pooled sensitivity increased to 0.76 (95% CI 0.70–0.80) for pre-eclampsia subgroup and decreased to 0.26 (0.22–0.30) for non-gravid hypertension subgroup. This evidence concerns the gene AGTR1 and hypertensive disorder.