AGTR1 and hypertensive disorder: As seen in Figure 2, 6 studies were included in the pre-eclampsia subgroup,13–18 with 4 in the non-gravid hypertension subgroup.9,19–21 A strong association of AT1-AA was found with pre-eclampsia (pooled OR 32.84, 95% CI 17.19–62.74, Z = 10.57, P = 0.000), but weaker with non-gravid hypertension (pooled OR 4.18, 95% CI 2.20–7.98, Z = 4.35, P = 0.000).