AGTR1 and hypertensive disorder: A recent research demonstrated the prevalence of maternal transmission in the hypertensive subjects, and highlighted the role of X-chromosome single-nucleotide polymorphisms in this phenomenon.37 Interestingly, AT1-AA could be transmitted to offspring from mother via placenta and milk, as was previously reported.38 We infer that AT1-AA plays a pathological role in maternal high blood pressure, and also in hypertensive disorders of future generations.