Our data revealed that the heterogeneity was observed when meta-analysis was conducted in all studies (I2 = 65.6%), but it was eliminated in meta-analyses of each subgroup: pre-eclampsia (I2 = 28.5%) and non-gravid hypertension (I2 = 0.0%), and an association between AT1-AA and pre-eclampsia (OR 32.84) was much stronger than that between AT1-AA and non-gravid hypertension (OR 4.18). Here, AGTR1 is linked to Hypertension.