The most common sequelae were xerostomia, neck fibrosis, tinnitus or hearing loss, trismus, glossolalia, radiation encephalopathy, anxiety, luteinizing hormone/follicle stimulating hormone (LH/FSH) deficiency, hypothyroidism, pulmonary fibrosis (mainly in the apex), growth hormone (GH) deficiency, and secondary malignancy. This evidence concerns the gene PLOD1 and Tinnitus.