The most broadly accepted definition of biochemical “cure” of acromegaly resulting from the American Association of Clinical Endocrinologists (AACE) is normalization of the basal GH level <2.5 mg/L, suppression of GH to 1 mg/L during the oral glucose tolerance test, and normal IGF-I for age and sex.6 The GH nadir was >1 ng/mL during a 75 g oral glucose tolerance test and the elevated IGF-1 level for the patient's age and sex, which indicates incomplete remission (Table 2) and necessitated further medical therapy. The gene discussed is IGF1; the disease is acromegaly.