In addition, the morphology of JIA SFbs resembled the one obtained in vitro by activating healthy subjects-derived SFbs with classic and non-classic Th1 supernatants, suggesting that in vivo, the TNF-α rich microenvironment of inflamed joints of JIA patients, may favour a cytoskeleton reorganization leading to morphological changes and ultimately resulting in “transformed phenotype” of these cells [24]. This evidence concerns the gene TNF and juvenile idiopathic arthritis.