We saw upregulation of hsa-miR-196a-5p and hsa-miR-196b-5p in colorectal carcinoma tissue as compared to normal colorectal mucosa; we subsequently saw a direct relationship with hsa-miR-196a-5p and HOXB7 and hsa-miR-196b-5p with HOXA10 in colonic carcinoma tissue. This evidence concerns the gene HOXA10 and colon carcinoma.