MAPK3 and lymphoma: Interestingly, constitutive expression and relative involvement of p38 in malignant transformation have been demonstrated in a large number of B-lymphoma-derived cell lines and primary lymphoma tissues.[42] Besides, inhibition of Erk1/2 phosphorylation has been shown to have anti-proliferative and pro-apoptotic activity in different lymphoma cell lines over normal lymphocytes, supporting the role of these MAPKs in lymphomagenesis.[27]