Akt, MAPK, and NF-κB signaling cascades have a crucial role in regulating cell cycle and proliferation.[27] Based on these evidences, we analyzed the effects of TLR1/2 or TLR5 ligands on the expression of cyclin D1 and cyclin D3 in MCL cell lines and short-term cultures derived from patients with MCL. The gene discussed is AKT1; the disease is mantle cell lymphoma.