TLR5 and mantle cell lymphoma: Interestingly, TLR2 and TLR5 variants have been identified with increased risk of several tumors, including MALT-lymphoma.[20] Furthermore, it has been recently demonstrated that TLR2 mutations may contribute to the pathogenesis of a subset of MCL by modulating tumor microenvironment responses.[21] Thus, aiming to identify new therapeutic targets for counteracting the tumor promoting effects of lymphoma microenvironment, we extensively investigated the role of TLR2 and TLR5 and their signaling in MCL cells.