Indeed, TLR2 and TLR5 were shown to regulate tumor tolerance, cancer progression and metastasis, although with effects that may vary according to cancer cell type.[10,14,17] TLR2 can form heterodimers with TLR1 or TLR6 to recognize diacylated and triacylated bacterial lipoproteins,[18] whereas TLR5 is a receptor for flagellin, a component of bacterial flagella.[19] Therefore, local infections by microorganisms producing PAMPs activating these TLRs could influence the growth and survival of MCL cells, particularly at distinct anatomic sites. This evidence concerns the gene TLR6 and cancer.