CVID patients with monoallelic TACI mutations had a higher frequency of autoimmune cytopenias than TACI wild-type patients (54% versus 13%, p < 0.0001); in particular, patients with TNFRSF13B C104R mutations had a higher prevalence of ITP (50% versus 10%, p = 0.05), whereas patients with non-C104R TNFRSF13B mutations had a higher frequency of AHA (44% versus 5%, p = 0.002). Here, TNFRSF13B is linked to autoimmune hemolytic anemia.