TNFRSF13B and Autoimmunity: In fact, patients with biallelic TACI mutations had a similar incidence of autoimmunity and lymphoproliferation signs compared to wild-type TACI patients, endorsing the hypothesis that if monoallelic TACI mutations reduce the elimination of autoreactive B-cells during the establishment of central B-cell tolerance, biallelic TACI mutations repress B-cell activation, preventing the development of autoimmunity.