The same was observed for specific IgA: CVID patients carrying biallelic mutations had higher prevaccination IgA anti-23-valent polysaccharide antigens compared to wild-type CVID (7 mU/mL ± 8 versus 0.3 mU/mL ± 0.8, p < 0.0001). Here, CD79A is linked to common variable immunodeficiency.