SREBF1 and steatosis: In parallel with the development of steatosis, the mRNA expression levels of lipogenic transcription factors like sterol regulatory element-binding protein 1c (SREBP1c) and carbohydrate responsive element-binding protein (ChREBP) as well as their target genes like fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1) increased greatly after OA administration (Figure 5, p < 0.001 versus untreated).