Previous studies have shown that hyperglycemia increases inflammatory mediators like different cytokines, which consequently facilitates inflammation condition and leads to inflammation.12 Expression of a large number of inflammation proteins is increased via NF-KB.20 In contrast to many studies done about the role of NF-KB in different systems like the immune system, there are a few studies on the role of NF-KB in the nervous system. This evidence concerns the gene NFKB1 and Hyperglycemia.