Diabetes mellitus is a complex disease which is characterized by chronic hyperglycemia with a disturbance in the metabolism of carbohydrates, fats, and proteins.1 This disease occurs due to the disturbance in insulin secretion, insulin operation, or both, and about 8% of the American population is suffering from it.2-5 In addition to the factors like food diet, lifestyle, and obesity, factors such as genetic history and changes in the gene expression have also been considered the effective factors for the development and progression of this disease. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.