PLOD1 and Hyperinsulinemia: On the other hand, the combination ofinsulin resistance and hyperinsulinemia seems toincrease the circulation of androgen levels (22,23), and induce constant production of LH (24).Insulin, androgens and estrogens raise mitotic activitythrough insulin-like growth factor (7, 18).All These alterations motivate endometrial proliferationand mutagenic potential, which mayelevate the risk of endometrial hyperplasia andca ncer (18).