The mechanisms which cause endometrialhyperplasia and carcinoma are possibly hyperestrogenemia.Hyperandrogenism, hyperinsulinemiaand obesity are also risk factors (19, 20).Hyperinsulinemia stimulates adrenal and ovarianandrogen production, endogenous estrogen productionfrom progesterone, and it also decreaseshepatic sex hormone binding globulin production(18, 21). The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.