Some studies have recently mentioned that the risk genotypes of rs1927914 are significantly linked with diabetic foot ulcers [29]; the research team of Singh [30] also found that the combined genotype risks of TLR4 SNPs rs10759931 (odds ratio [OR] 1.50, p = 0.05) and rs1927914 (OR 1.48, p = 0.05) were significantly linked to retinopathy in T2DM. Here, TLR4 is linked to diabetic foot.