Assessment of peripheral monocytes, total DCs, BDCA1+ DCs, and CD14−/lowCD16+ DCs by Henriques et al. showed that a higher percentage of SLE monocytes and CD14−/lowCD16+ DCs produced proinflammatory cytokines as well as a higher amount of cytokines produced per cell, particularly in active disease. The gene discussed is CD14; the disease is systemic lupus erythematosus.