Figure 1 shows the results of such an experiment. Cells treated with the negative-control siRNA displayed the expected loss of TFIIH-p62 and PKR when infected with NSs-expressing recombinant WT RVFV (rZH548), whereas infection with the NSs-deficient RVFV mutant strain clone 13 (Cl13) spared both proteins (Fig. 1A). Here, EIF2AK2 is linked to infection.