Univariate Cox analysis showed that CHI3L1 mRNA expression (p < 0.001), astrocytoma pathological grade (p < 0.001) and patient age (p < 0.001) had a significant association as independent variables with the overall survival of the patients, while CHI3L1 promoter methylation status and patient gender had no significant connection (p > 0.05). This evidence concerns the gene CHI3L1 and astrocytoma (excluding glioblastoma).