Vo et al. reported that CaBP-9k mRNA and protein expression can be significantly induced by MP, EP, and other parabens at a level of 10−4 M (approximately 15.2 ppm for MP and 16.6 ppm for EP, which are near the doses of MP and EP used in this study) in GH3 rat pituitary cancer cells and demonstrated that estrogen receptor is involved in the induction of CaBP-9k by parabens in GH3 cells30. The gene discussed is ESR1; the disease is pituitary cancer.