Functional loss of TRPA1 channels markedly reduced the levels of the inflammatory cytokines IL-1β, IL-6 and IL-4 (n = 8, P < 0.05) but not anti-inflammatory cytokine IL-10 (n = 8, P > 0.05) in AD brains (Fig. 4c-f). This evidence concerns the gene TRPA1 and Alzheimer disease.