In astrocytes, Aβ elicits the production of ROS and nitric oxide (NO), which can activate TRPM2, TRPM7, TRPC5 and TRPV1 and increase the intracellular level of Ca2+, thereby leading to AD-related events in the brain including neurodegeneration and inflammation [30]. The gene discussed is TRPM7; the disease is Alzheimer disease.