We determined the expression of TRPA1 channels in vivo by using wild-type (WT) and APP/PS1 transgenic (Tg) mice, then investigated whether the TRPA1 channel plays a role in the development of AD by using APP/PS1 Tg and APP/PS1 Tg/TRPA1−/− mice. The gene discussed is PSEN1; the disease is Alzheimer disease.