Although we do not know how this IL-1α 3′ UTR variant influences the recurrence risk of tumor HPV16-positive patients, it is biologically plausible that this variant may be either functional or in linkage disequilibrium with other functional variants of IL-1α, thereby altering the function of IL-1α, or with alleles at other nearby susceptibility loci. The gene discussed is IL1A; the disease is neoplasm.