CDH1 and colorectal carcinoma: A total of 5 germline variants were detected on 4 genes, among which a missense variant in the E-cadherin gene (CDH1) T340A (COSMIC19821) was present in 3 patients with CRC (Sample ID 1307, 1705, 1738), which represented a germline mutation hotspot in our population (6%, 3/50).