Accumulated data showed that TGF-β plays double-edged roles in HCC, working as a tumor suppressor to inhibit cell growth at early stages of liver damage and regeneration, while as a tumor promoter to induce epithelial-mesenchymal transition (EMT) and enhance cancer metastasis and invasion in advanced HCC [9]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.