Second, as shown in Figure 5A, PPM1a staining was mostly localized in the cytoplasm of pericarcinous liver tissue and HCC tissue, while its expression in HCC tissue was dramatically weaker than that in paired surrounding non-cancerous tissue (P < 0.0001), which is consistent with the tumor suppressor role of PPM1a in liver cancer. Here, PPM1A is linked to hepatocellular carcinoma.