Alternatively, hypoxia stimulates tumor cell migration and invasion via increased activation of matrix metalloproteinases, remodeling of the extracellular matrix [3], activation of signaling molecules including Focal Adhesion Kinase (FAK) and Rac1 [9–11], and by activating pathways initiated by growth factors [12], amongst other events (Reviewed in [6]). The gene discussed is RAC1; the disease is neoplasm.