Given the critical role of BCL-9 in Wnt signaling pathway promoting carcinogenesis and chemo-resistance, the specific regulation of BCL-9 expression by HIF-1α is considered to be a underlying crosstalk between Wnt signaling and hypoxia signaling pathway, providing foundation for further study to develop new target of potential therapeutic strategies by blocking HIF-1α/BCL-9 signaling related expression in CRC. Here, BCL9 is linked to colorectal carcinoma.