The positive expression of BCL-9 was observed in all stages of CRC samples (13.9% in stage I, 10 of 72 cases; 47.4% in stage II, 63 of 133 cases; 55.8% in stage III, 43 of 77 cases; and 100% in stage IV, 2 of 2 cases). This evidence concerns the gene BCL9 and colorectal carcinoma.