ZD55, that had been extensively reported to possess significant cancer-killing effect, was further modified into The novel oncolytic adenovirus GD55was designed using GP73 promoter to promote the specificity and high efficiency of GD55 replication for hepatocellular carcinoma based on ZD55 [17], consistent with our results that GD55 exerted more excellent cytotoxic effect for liver CSCs-like cells than that of ZD55. This evidence concerns the gene GOLM1 and cancer.