In vivo experiments also confirmed that GP73-regulated GD55 held an increased inhibiting ability of tumor growth in BALB/c nude mice xenograft with liver sphere cells, to some extent through apoptosis inducement, anti-proliferative and anti-angiogenisis mechanisms within implanted tumors, which is consistent with some of the studies on other cancer-targeting oncolytic adenovirus types [35]. The gene discussed is GOLM1; the disease is cancer.