CMTM3 is also downregulated in 84% of renal cell carcinoma (63/75); Restoration of CMTM3 in a renal cell carcinoma cell line inhibits cell proliferation and migration [6]; CMTM3 expression is significantly reduced in OSCC cell lines and primary tumor specimens. Here, CMTM3 is linked to hereditary clear cell renal cell carcinoma.