STAT3 and cancer: EMT transcription factors Zeb1 [16, 17], Snail [17, 18] and Twist1 [18, 20] are important players in the regulation of EMT during cancer metastasis through different signaling cascades, including the Akt [22, 22], Erk1/2 [22] and signal transducer and activator of transcription 3 (STAT3) [23] signaling pathways.