It was found that B7-H3Bi-armed ATC secreted more IFN-γ, TNF-α and IL-2 than unarmed ATC, and had enhanced cytotoxic activity against a wide range of human cancer cells, including lung cancer, breast cancer, colorectal cancer, pancreatic cancer, cervix cancer, prostate cancer, and glioblastoma. This evidence concerns the gene IL2 and Familial prostate cancer.