It was found that B7-H3Bi-armed ATC secreted more IFN-γ, TNF-α and IL-2 than unarmed ATC, and had enhanced cytotoxic activity against a wide range of human cancer cells, including lung cancer, breast cancer, colorectal cancer, pancreatic cancer, cervix cancer, prostate cancer, and glioblastoma. The gene discussed is TNF; the disease is lung cancer.