By conducting association studies in two independent Chinese populations containing 1327 cases and 2075 controls in total, we replicated the significances of tag SNP rs8180040, and found a significant protective effect for the potentially regulatory variant rs1076394 that might serve as an eQTL for the genes CCDC12 and NME6, while NME6 presented significantly higher expression in cancer tissues. This evidence concerns the gene CCDC12 and cancer.