CCDC12 and cancer: As the presumed regulatory variant rs1076394 was in complete LD with rs8180040 in the 1000 Genomes database, rs1076394 was also indicated as being closely related to the expression of CCDC12 and NME6. In addition, we compared the two genes’ expression between cancer and normal tissue, and found a significant difference for NME6 (P = 0.029; CRC tissues: 229.5 ± 3.2 RPKM (reads per kilobases per million reads), peritumoral tissue: 210.5 ± 5.4 RPKM), but not for CCDC12 (P = 0.258; CRC tissues: 707.7 ± 15.3 RPKM, peritumoral tissue: 661.6 ± 16.49 RPKM).