Furthermore, in cohort 1, we found several miRNAs to be significantly (uncorrected P < 0.05, Wilcoxon rank test) differentially expressed in primary tumor tissue samples from patients with metastatic vs. non-metastatic PC or from RP patients with pT3-4 vs. pT2, high (≥ 7) vs. low (< 7) Gleason score, or +/− BCR after surgery (Supplementary Tables S3–S6). The gene discussed is BCR; the disease is pachyonychia congenita.