Recently, it has been demonstrated that miR-675 have several targets in different cancers, such as c-Cbl and Cbl-b in breast cancer [5], GPR55 in lung carcinoma [26], Rb in colorectal cancer [17], CALN1 in gastric cancer [14], Cadherin 11 in melasma [39]. The gene discussed is GPR55; the disease is freckles.