RAC1 and esophageal squamous cell carcinoma: As noted in our manuscript, knockdown of miR-675-5p in ESCC cells induced cell G1 arrest, down-regulated CyclinD1 which was correlated with G1-S phase transition and inhibited REPS2/RalBP1/RAC1/CDC42 signaling pathway, which might be responsible for the effect of miR-675-5p on proliferation of ESCC cells.