TP53 and neoplasm: We propose that increased glucose uptake in the progression from pre-neoplastic to neoplastic liver cells and the metabolic shift from aerobic to anaerobic metabolism (Warburg's effect), typical of cancer [43, 44], affect the physiologically negative regulation of miR-483-3p and the miR-145/TP53 axis, dampening the anti-tumoral effect of this pathway and facilitating tumor development.