Since mutations in TP53 and β–catenin are mutually exclusive in HCC [20], we speculate that the HCCs that show TP53 mutations, and consequent down regulation of PUMA, p21 and other TP53 targets, do not need the up-regulation of miR-483-3p to reduce the apoptotic rate. This evidence concerns the gene CDKN1A and hepatocellular carcinoma.