Interestingly 4 out of these 5 deregulated miRNAs are involved in resistance to apoptosis: miR-483-3p is known to target BBC3/PUMA in HCC and CRC [26, 38]; miR-197 is deregulated in lung cancers harbouring wild type TP53 [39]; miR-940 and miR-630 are up-regulated in cisplatin-resistant lung and head and neck cancers [40–42]. Here, BBC3 is linked to head and neck cancer.