Moreover, markers that induce or indicate EMT in colon cancer were significantly overexpressed in tumors with high CYB5R1 levels, including ZEB1 (r=0.20, p<0.0001), TWIST1 (r=0.22, p<0.0001), and VIM (r=0.29, p<0.0001) (Figure 3B). The gene discussed is ZEB1; the disease is malignant colon neoplasm.