Considering our previous results and to study the functions of pro-BDNF, p75NTR and TrkB, in clear cell RCC, two human cell lines derived from RCC were used, a primary renal cell carcinoma (786-O) [35] and a metastatic renal cell carcinoma (ACHN) [36]. Here, BDNF is linked to hereditary clear cell renal cell carcinoma.