Notably, mutations in NF-L have been associated to some forms of Charcot-Marie-Tooth (CMT) disease, causing alteration of NF-L assembly and inhibiting axonal transport of NF-L and mitochondria, thus an effect of NF-L mutations on vesicle transport cannot be excluded in these forms of CMT [132]. Here, NEFL is linked to Charcot-Marie-Tooth disease.