TP53 and cancer: Aminoglycosides G418 (geneticin) and gentamicin are validated read-through correctors in different experimental cell systems and demonstrated to possess the ability to restore full-length production of the cystic fibrosis transmembrane conductance regulator (CFTR) in a bronchial cell line carrying a nonsense mutation in the CFTR gene [33], a functional full-length p53 protein in human cancer cell line containing a PTC [34] and the biological activity of the adenomatous polyposis coli PTC-gene in human cancer cells [35].