IL27RA and neoplasm: In support of these notions, accumulated evidence from clinical studies has shown that IL-27 and IL-27R are present in various tumor types from patient specimens, and significantly increased serum levels of IL-27 correlate with tumor growth and disease progression (Larousserie and others 2005, 2006; Diakowska and others 2013; Gonin and others 2013; Lu and others 2014).