Unexpectedly, treatment with IL-27 at concentrations up to 200 ng/mL had no effects on cell growth of 3 other leukemic cell lines, the AML cell lines, KG-1 and U937, and the acute T-cell leukemic cell line, Jurkat, despite the surface expression of the full IL-27R complex (data not shown). Here, IL27 is linked to acute myeloid leukemia.