al. reported downregulation of miR-320d in colon cancer stem cells (CD133+) compared to CD133- cells in HT-29 CRC cells, which is concordant with our data implicating miR-320 in regulating CRC tumor initiating cells using in vitro clonogenic and in vivo tumor formation assays [14]. Here, PROM1 is linked to malignant colon neoplasm.