For instance, PINK1 deficient-mice had enhanced oxidative stress and higher degrees of cardiomyocyte apoptosis [33] Kubli and coworkers [34] showed that mice with global deletion of Parkin were more sensitive to myocardial infarction, which was mainly attributed to the impaired mitophagy in cardiomyocytes. This evidence concerns the gene PINK1 and myocardial infarction.