Conversely, apical SLC9A3R1 intensity provides readout of PRKCZ [36] a key morphogenic effector of the PTEN/CDC42/PRKCZ pathway [11], has prognostic relevance in human CRC and predicts 1,25(OH)2D3 control of gland morphology. This evidence concerns the gene NHERF1 and colorectal carcinoma.