CCND1 and mantle cell lymphoma: From the therapeutic standpoint, small-molecule CDK inhibitors such as CYC202 (Seliciclib, R-roscovitine), a purine analogue and a selective inhibitor of cdk2-cyclin E, cdk7-cyclin H, and cdk9-cyclin T has been shown to induce increased expression of apoptosis regulatory genes and decreased Cyclin D1 in MCL cell lines REC, Granta-519, JeKo-1, and NCEB-1 [140].