Interestingly, GUT-70 demonstrated antiproliferative effects in forms of MCL in which p53 was mutated (mt-p53); it induced mitochondrial apoptosis with upregulation of NOXA and downregulation of Mcl-1 in mt-p53 cells, but affected only Mcl-1 expression in cells with wild type p53, indicating the specific activity of GUT-70 toward pathways affected by mutant p53 [174]. The gene discussed is PMAIP1; the disease is mantle cell lymphoma.