The combination of 17-DMAG and HDAC inhibitor vorinostat exhibited a synergistic effect culminating in cell cycle arrest at G2/M and G1 and decreased expression of Cyclin D1, cdk4, c-Myc, c-RAF, and AKT leading to extensive apoptosis in MCL cell lines and primary cells [173]. Here, CDK4 is linked to mantle cell lymphoma.