Therefore, a current recommendation includes shortened conventional chemotherapy induction followed by consolidating radiation for MCL patients carrying high tumor burden (> 5 cm are presented below) and/or having poor prognostic factors (blastoid features, high Ki67 indices (> 20-40%), high β2 microglobulin (> 3 mg/l), and central nervous system involvement [6, 90]. The gene discussed is MKI67; the disease is neoplasm.