MCL1 and mantle cell lymphoma: Several reports have suggested that treatment with NVP-BEZ235 could inhibit mTORC1 and mTORC2, as well as PKI3, and induce apoptosis of MCL cells by down-regulating constitutive Mcl-1 expression in chemo-naive MCL cell lines [157] and in bortezomib-resistant cell lines [158].