However, the downregulated mRNAs were involved in the PPAR signaling pathway, mRNA surveillance pathway, RNA degradation, protein processing in the endoplasmic reticulum, and processes related to many diseases (Huntington's disease, Parkinson's disease, and Alzheimer's disease) associated with aging (S8 Table). The gene discussed is PPARA; the disease is early-onset autosomal dominant Alzheimer disease.