EPAS1 and hepatocellular carcinoma: Bangoura et al. suggested that HIF-2α played a positive role in promoting HCC because the high level of HIF-2α was associated with tumor angiogenesis and a poor outcome [14], whereas Sun et al. found that the high level of HIF-2α protein was correlated with a good outcome in patients with HCC and that the expression of pro-apoptotic proteins was much more higher in HCC patients with high HIF-2α than those with low HIF-2α [15].