EPAS1 and cirrhosis of liver: Furthermore, HIF-2α levels and other clinicopathlogical variables including gender, age, tumor diameter, number of tumor lesions, presence of liver cirrhosis, preoperative serum alanine aminotransferase, bilirubin, AFP and albumin level, histologic differentiation, and macroscopic vascular invasion were included in a multivariable model using Cox regression.