To investigate the effect of HIF-2α on the expression of Bak, ZBP-89 and PDCD4 in vivo, we detected the expression of HIF-2α, Bak, ZBP-89 and PDCD4 in xenograft tumor tissues by real-time PCR, western blotting and immunohistochemical staining analysis. The gene discussed is EPAS1; the disease is neoplasm.