To investigate the effect of HIF-2α on the expression of Bak, ZBP-89 and PDCD4 in vivo, we detected the expression of HIF-2α, Bak, ZBP-89 and PDCD4 in xenograft tumor tissues by real-time PCR, western blotting and immunohistochemical staining analysis. This evidence concerns the gene PDCD4 and neoplasm.