Appreciating the success of other viruses designed to amplify both cancer-cell destruction with release of tumor-specific immunogenic epitopes and subsequent immunostimulation through expression of, e.g., GM-CSF,3,44 CG0070, an Ad5 serotype Adenovirus, which is dependent on Rb (retinoblastoma)-defectiveness, is also coding for GM-CSF. The gene discussed is RB1; the disease is retinoblastoma.