To determine whether high-resolution microSPECT/CT imaging could be used to detect and resolve multiple individual intratumoral infectious foci, immunocompetent BALB/c mice bearing subcutaneous MPC-11 plasmacytomas (5 mm approximate diameter) were given a single intravenous dose of VSV-mIFNβ-NIS (5 × 106 to 1 × 108 TCID50) and imaged 24 hours later. This evidence concerns the gene SLC5A5 and plasmacytoma.