IL1B and colon adenocarcinoma: In agreement with our results, Dumont and coworkers (2008) have shown that the supernatants from LPS-activated, therefore M1-like macrophages, contained high levels of proinflammatory cytokines such as GM-CSF, IL-1β, IL-6, IL-8, and TNF-α and exhibited growth inhibitory activities on human colon adenocarcinoma cells [54].