ERBB2 and adenocarcinoma: In a study involving 99 patients, the 7p12 (C-myc), 8q24.12 (EGFR), and 20q13.2 genes were mostly amplified in severe dysplasia and adenocarcinoma, suggesting that the correlation between ESCC and HER2 is not exact (Rygiel et al. 2007).