IGF2 and melanoma: DNA hypomethylation has been implicated in the activation of the growth promoting genes such as related-RAS (R-Ras) and mammary serine protease inhibitor (MAPSIN) for gastric carcinoma, S-100 in case of colonic cancer, melanoma-associated antigen (MAGE) in melanoma [15], and loss of imprinting, especially of insulin like growth factor 2 (IGF-2) as seen in Wilms' tumor [16] and colorectal cancer [17].