The Phosphatase PTEN (Phosphatase and tensin homolog) physiologically inhibits the downstream activity of PI3K/AKT axis and is frequently deregulated in HCC (66% of tumor incidence in PTEN-deficient mice) [81]; moreover, it is correlated with poor prognosis and more frequent metastasis [82]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.