AFP and clostridium difficile infection: It was difficult to distinguish on MRI between LCH and germinoma because LCH can be single system that only involves the hypothalamic-pituitary system; tumor markers such as AFP and β-HCG in the blood and central spinal fluid can be negative in the early stage of the tumor; and LCH and germinoma could share the same findings in some cases when CDI was diagnosed.