SIRT6 and coronary artery disorder: By χ2 test and logistic regression analysis, we found that rs352493 polymorphism in SIRT6 exhibited a significant effect on the severity of CAD in the Chinese Han population; C allele (χ2 = 7.793, P = 0.005, and adjusted P = 0.013) and the combined CC/CT genotypes (χ2 = 5.609, P = 0.018, and adjusted P = 0.031) tended to have greater CAD severity.