Alternatively, SIRT6 tagSNP rs4807546 showed no significant association with the risk of Parkinson's disease in a Spanish population [34], and the SIRT6 polymorphisms (rs350852, rs7246235, rs107251, and rs350844) were not associated with diabetic nephropathy in a combined meta-analysis as well [35]. This evidence concerns the gene SIRT6 and Parkinson disease.