However, we found that the rs352493 polymorphism in SIRT6 exhibited a significant effect on the severity of CAD; C allele (χ2 = 7.793, adjusted P = 0.013) and the combined CC/CT genotypes (χ2 = 5.609, adjusted P = 0.031) presented the greater CAD severity. The gene discussed is SIRT6; the disease is coronary artery disorder.